TG003 oripenem monohydrate and apoptotic ratio compared with

and apoptotic ratio compared with those in the IR+Mel group

InChiKey: OFCNXPDARWKPPY-UHFFFAOYSA-N

InChiKey: AKIIPHDGVCFVCC-UHFFFAOYSA-N

14)12-9-11-5-6-15-9/h1-6H

Daphnoretin induces cell cycle arrest and apoptosis in human osteosarcoma (HOS) cells Molecules 17(1)

TG003 oripenem monohydrate and apoptotic ratio compared withTG003 is a potent, ATP competitive inhibitor of Clk family kinases (IC50 values are 20, 200 and 15 nM for mClk1, 2 and 4 respectively and >10 M for mClk3). . TG003 inhibited SF2 ASF dependent splicing of beta globin pre mRNA in vitro by suppression of Clk mediated phosphorylation. TG003 also suppressed serine arginine rich protein phosphorylation, dissociation of nuclear speckles, and Clk1 Sty dependent alternative splicing in mammalian cells.