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Formula: C16H18N4O2
It increases the knock-in efficiency by two- to five-fold at different loci
Smiles: COC1=CC2=CC=C(C=C2C=C1)C(C)C(=O)OC1C=CC(=CC=1)C(N)=S
AG-120 is well tolerated to date (10/2015) and MTD was not reached
When mice that were transplanted with primary mouse T-ALL cells
ML228 - HIF Pathway Activator. CAS# 1357171-62-0 0161 Formula: C16H18N4O2ML228, CAS No. 1357171 62 0, is a hypoxia inducible factor (HIF) pathway activator with an EC50 at ~1. 23 M in HRE gene reporter assay and ~1. 4 M in HIF 1 nuclear translocation assay. It does not inhibit the proteasome, but activates HIF stabilization and nuclear translocation, and induces expression of a HIF specific downstream gene (VEGF). It has no apparent toxicity below 30 M and appeared to be an iron chelator, independently of PHD. HIFs are
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