K-756 opam hydrochloride 1H2/b2*13-12+

1H2/b2*13-12+

33S)-33-[(E

2006 Mar 21

Smiles: CN(C)S(=O)(=O)NC(=O)[C@@]1(O)CC(=O)N(C)CCC=C[C@H](OCCN2CC(F)(F)C2)[C@@H]2CC[C@H]2CN2C[C@]3(COC4=CC=C1C=C24)CCCC1=CC(Cl)=CC=C31 |t:18|

9 nM for rP2X1R and rP2X3R

K-756 opam hydrochloride 1H2/b2*13-12+K 756 is a direct and selective tankyrase (TNKS) inhibitor, which inhibits the ADP ribosylation activity of TNKS1 and TNKS2 with IC50s of 31 and 36 nM, respectively. Product information CAS Number: 130017 40 2 Molecular Weight: 433. 50 Formula: C24H27N5O3 Chemical Name: 3 {[1 (6,7 dimethoxyquinazolin 4 yl)piperidin 4 yl]methyl} 1,2,3,4 tetrahydroquinazolin 2 one Smiles: COC1=CC2=NC=NC(=C2C=C1OC)N1CCC(CN2CC3C=CC=CC=3NC2=O)CC1 InChiKey: GWXCGEJJQFHPPA