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4-benzodiazepin-1-yl)acetohydrazide
Formula: C24H25Cl2N5O3
InChi: InChI=1S/C9H14N3O7P/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(19-8)4-18-20(15
Animal Model: Female BALB/C-nu mice bearing established BaF3-tel-c-KIT-T670I tumor xenografts
Smiles: CC1C=C(C(=CC=1C(=O)NC(N)=N)S(C)(=O)=O)N1C=CC=C1
ARL 17477 dihydrochloride B2 Ligand 4-benzodiazepin-1-yl)acetohydrazideARL 17477 dihydrochloride is a selective and potent neuronal nitrogen oxide synthase (nNOS) inhibitor with IC50 values of 1 and 17M for nNOS and endothelial NOS, respectively . Neuronal NOS (nNOS) plays an important role in the development of ischaemic brain necrosis while endothelial NOS (eNOS) protects brain tissue through increasing ischaemic regional cerebral blood flow . In rats after transient MCA occlusion, ARL 17477 (1mg kg, 3mg kg and 10mg
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