RepSox - TGF-β Type I Receptor ALK5 Inhibitor. CAS# 446859-33-2 0273 LGK974 is a highly potent

LGK974 is a highly potent

It is a useful tool compound to modulate stem cell differentiation (for example

EMCS crosslinking reagent's NHS ester and maleimide reactive groups react with amino and sulfhydryl moieties

which is the first selective and potent inhibitor of the H3K27 histone demethylases UTX and JMJD3

HIF-C2 provides an opportunity to delineate differences in HIF-1 and HIF-2 biology and serves as an entry point for development of HIF-2 inhibitor drugs for treating diseases

RepSox - TGF-β Type I Receptor ALK5 Inhibitor. CAS# 446859-33-2 0273 LGK974 is a highly potentRepSox (E 616452 or SJN 2511), CAS No. 446859 33 2, is a highly potent, selective inhibitor of the TGF type I receptor ALK5 with IC50 of 23 nM and 4 nM for ATP binding to ALK5 and ALK5 autophosphorylation, respectively. It has good selectivity for ALK5 over a range of kinases, including p38 MAPK, JNK1 and GSK3 (IC50 > 16 M). RepSox is able to successfully replace Sox2 in reprogramming by inhibiting transforming growth factor (Tgf ) signaling, which in