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These values corresponded well to the cellular IC50 for PF-AKT400 in U87 cells measuring p-GSK-3α (310 nM)
TAK-960 hydrochloride (8 nM) leads to G2/M cell cycle arrest without significant cytotoxicity in HeLa cells
Smiles: CN1CCN(CC1)C(=O)C1C=CC(=CC=1)NC(=O)NC1C=CC(=CC=1)C1=NC(=C2N=NN(CC)C2=N1)N1CCOCC1
4-diazepan-1-yl)(5-methyl-2-(2H-1
TH588 (2-10μM
m-PEG3-Sulfone-PEG4-propargyl 1082 These values corresponded well tom PEG3 Sulfone PEG4 propargyl is a PEG based PROTAC linker that can be used in the synthesis of PROTACs. Product information CAS Number: 2055041 02 4 Molecular Weight: 426. 52 Formula: C18H34O9S Chemical Name: 1 {2 [2 (2 methoxyethoxy)ethoxy]ethanesulfonyl} 3,6,9,12 tetraoxapentadec 14 yne Smiles: COCCOCCOCCS(=O)(=O)CCOCCOCCOCCOCC#C InChiKey: RZOCFVBQMWCPJD UHFFFAOYSA N InChi: InChI=1S C18H34O9S c1 3 4 22 7 8 24 9 10 25 12 14 27 16 18 28(19,20)17 15
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