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Solubility: DMSO up to 15 mM
84(2):110-5
Smiles: COC1=CC2=NC=CC(OC3=CC(Cl)=C(C=C3)NC(=O)NC3CC3)=C2C=C1C(N)=O
Linifanib shows a Cmax and AUC24 hours with 0
Iremashvili VV
Neratinib (HKI-272) vinostat) Solubility: DMSO up to 15Neratinib, also known as HKI 272 or PB272, is an orally available, irreversible inhibitor of the HER 2 receptor tyrosine kinase with potential antineoplastic activity. Neratinib binds to the HER 2 receptor irreversibly, thereby reducing autophosphorylation in cells, apparently by targeting a cysteine residue in the ATP binding pocket of the receptor. Product information CAS Number: 698387 09 6 Molecular Weight: 557. 04 Formula: C30H29ClN6O3 Synonym:
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