Furamidine dihydrochloride - PRMT1 Inhibitor. CAS# 55368-40-6 0113 Smiles: NC1N=C(COC(=O)C2C=CC(=CC=2)[N+]([O-])=O)N=C(NC2C=CC=CC=2)N=1

Smiles: NC1N=C(COC(=O)C2C=CC(=CC=2)[N+]([O-])=O)N=C(NC2C=CC=CC=2)N=1

3 to 3 mg/kg orally) significantly inhibited the progression of arthritis and joint destruction in type II collagen-induced arthritis (CIA) in DBA/1J mice

InChiKey: GJFCSAPFHAXMSF-UXBLZVDNSA-N

Smiles: CN(C)C1NC2=C(N=1)C(Br)=C(Br)C(Br)=C2Br

Acalabrutinib demonstrates on-target effects including decreased phosphorylation of PLCγ2

Furamidine dihydrochloride - PRMT1 Inhibitor. CAS# 55368-40-6 0113 Smiles: NC1N=C(COC(=O)C2C=CC(=CC=2)[N+]([O-])=O)N=C(NC2C=CC=CC=2)N=1Furamidine, CAS No. 55368 40 6, is a potent, selective and cell permeable Protein arginine methyltransferase 1 (PRMT1) inhibitor with IC50 of 9. 4 M. It has >10 fold selectivity PRMT5, PRMT6 and CARM1 (IC50 are 166, 283 and >400 M respectively). It targets the enzyme active site and is primarily competitive with the substrate and noncompetitive toward the cofactor. Furamidine effectively inhibits intracellular PRMT1 activity and blocks cell