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While the plasma levels of PD 153035 falls below 1 μM by 3 hours
InChi: InChI=1S/C14H14ClFN8/c1-7-3-11(24-23-7)21-13-10(15)6-19-14(22-13)20-8(2)12-17-4-9(16)5-18-12/h3-6
InChiKey: ZGUSBCDCZNBNQT-UHFFFAOYSA-N
and highlights a tractable pathway for future drug discovery efforts
Chemical Name: (E)-5-chloro-2-(2-(phenyl(pyridin-2-yl)methylene)hydrazinyl)pyridine
IRE-3 - IRE1a Modulator. CAS# 1414938-21-8 60319 While the plasma levels ofIRE 3, CAS No. 1414938 21 8, is a highly potent and selective small molecule modulator of IRE1. Under endoplasmic reticulum stress, unfolded protein accumulation leads to activation of the endoplasmic reticulum transmembrane kinase endoRNase (RNase) IRE1. IRE1 oligomerizes, autophosphorylates and initiates splicing of XBP1 mRNA, thus triggering the unfolded protein response (UPR). Interestingly, IRE 3 inhibits the XBP1 mRNA splicing through binding to
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