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Chemical Name: (2S)-1-[(2S)-2-[(2S
Nakagawa K
CC-115 inhibits PC-3 cells proliferation with an IC50 of 138 nM
Intracerebroventricular pretreatment with SB-408124 (50 mM
4-triazin-3-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4
Cryptotanshinone Size:Solid 2 mg Chemical Name: (2S)-1-[(2S)-2-[(2SCryptotanshinone is isolated from the root of the Asian medicinal plant, Salvia miotiorrhiza bunge. The compound is a potent STAT3 inhibitor. Cryptotanshinone rapidly inhibited STAT3 Tyr705 phosphorylation through a JAK2 independent mechanism. Cryptotanshinone selectively inhibits STAT3 activated cell lines through binding to monomer STAT3, subsequently blocking the dimerization and inhibiting STAT3 transcriptional regulatory activity. It has been
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