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ALK5 and ALK7 (IC50≥500 nM)
Asaraldehyde down-regulates C/EBPβ
Rociletinib (50 mg/kg bid
oral gavage of C34 (1mg/kg/day) for 4 days attenuated the severity of NEC as demonstrate by marked preservation of the intestinal mucosa
After 4 days of treatment with PH-002 (200 nM)
Sunitinib D10 fenone D7 Hydrochloride ALK5 and ALK7 (IC50≥500 nM)Sunitinib D10 (SU 11248 D10) is a deuterium labeled Sunitinib. Sunitinib is a multi targeted receptor tyrosine kinase inhibitor with IC50s of 80 nM and 2 nM for VEGFR2 and PDGFR, respectively. Sunitinib, an ATP competitive inhibitor, effectively inhibits autophosphorylation of Ire1 by inhibiting autophosphorylation and consequent RNase activation. Product information CAS Number: 1126721 82 1 Molecular Weight: 408. 54 Formula: C22H27FN4O2 Chemical
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