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Formula: C17H20N6O4S
A phase I first-in-human trial of bardoxolone methyl in patients with advanced solid tumors and lymphomas
YM155 shows 80% TGI at a dose of 5 mg/kg in PC-3 orthotopic xenografts[1]
InChi: InChI=1S/C23H24ClN3O2/c1-25(2)18-9-5-16(6-10-18)23(17-7-11-19(12-8-17)26(3)4)21-15-20(27(28)29)13-14-22(21)24/h5-15
InChiKey: UJIAQDJKSXQLIT-UHFFFAOYSA-N
AZ 628 Size:Solid 2 mg Formula: C17H20N6O4SAZ 628 is a selective, orally available Raf inhibitor with excellent pharmacokinetic properties and robust tumor growth inhibition in xenograft studies ( (IC50 values are 29, 34 and 105 nM for c Raf1, B RafV600E and wild type B Raf, respectively). AZ 628 inhibits growth, and induces cell cycle arrest and apoptosis in colon and melanoma cell lines with the B RafV600E mutation. Product information CAS Number: 878739 06 1 Molecular Weight: 451. 52