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with potency similar to that of delamanid and greater than that of PA-824
oral administration to rats of CGP 37849 selectively blocks firing in hippocampal neurones induced by ionophoretically-applied NMDA
Solubility: DMSO : 125 mg/mL (172
3)44-27(43)39(12-17-4-5-22-21(8-17)37-26(42)40(22)13-23(34)41)18-6-7-29(10-18)14-38(15-29)24-20-9-19(11-30(31
In the pylorus-ligated (4 hr) rats
JNJ 303 4894 with potency similar to thatJNJ 303 is a potent IKs blocker with an IC50 value of 64 nM. JNJ 303 does not have any effects on other cardiac channels at concentrations of 3. 3 M for INa, Ica, Ito, and IKr. JNJ 303 induces QT prolongations and causes unprovoked torsades de pointes (TdP). Product information CAS Number: 878489 28 2 Molecular Weight: 440. 98 Formula: C21H29ClN2O4S Chemical Name: 2 (4 chlorophenoxy) 2 methyl N [(1R,2s,3S,5s,7s) 5 methanesulfonamidoadamantan 2
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