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dose-dependently increases the withdrawal latency of the ipsilateral hindpaw at 1-3 and 1-5 h after injection at days 3 and 7 postsurgery (SNL 3D+GSK and SNL 7D+GSK
VSMC) and inhibits AII-induced contraction in rabbit aorta (IC50 8
CN1C2=CC=CC=C2C2=C1CCN(CC1N=CNC=1C)C2=O
Wangemann P
Food and Drug Administration in 1998
Apogossypolone (ApoG2) Size:Contact [email protected] for quotation dose-dependently increases the withdrawal latencyApogossypolone is an inhibitor of Bcl 2, Mcl 1 and Bcl XL with Ki values of 35nM, 25nM and 660nM, respectively . The MTT based cell cytotoxicity assay shows that apogossypolone has an anticancer activity with IC50 values of 1, 2 and 3M, respectively in PC 3, DU 145 (human prostate cancer cell lines) and MDA MB 231(human breast cancer cell line). Apogossypolone is also found to inhibit the colony formation of DU 145 cells. The mechanism is that
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