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L-685458 - CAS# 292632-98-5 se sulfate Huazhongilexone

SKU: 82013761700

4.3
USD225.00 USD256.00

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Description

Huazhongilexone

which potently and selectively kills cells containing an MLL translocation

Dizocilpine maleate (< 500 μM) inhibits activation of microglia induced by LPS with increased Cox-2 protein expression in BV-2 cells

Pharmacokinetics of galanthamine in humans and corresponding cholinesterase inhibition

Bromberg J

L-685458 - CAS# 292632-98-5 se sulfate HuazhongilexoneL 685458 is a potent transition state analog (TSA) secretase inhibitor (GSI). L 685458 inhibits amyloid protein precursor secretase activity with IC50 of 17 nM, shows greater than 50 100 fold selectivity over other aspartyl proteases tested. L685458 inhibits secretase mediated cleavage of APP C99 and Notch 100 with IC50s of 301. 3 nM and 351. 3 nM, respectively. L 685458 can be used for the research of alzheimers disease (AD) and cancers. Product

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