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R-GNE-140 - CAS# 2003234-63-5 size:2mg solid Kd= 650 nM)

SKU: 82359833

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Description

Kd= 650 nM)

selective and cell permeable BRPF1 bromodomain inhibitor with IC50 ~ 80 nM

da Silva CR

InChi: InChI=1S/C19H22O4/c1-12(2)9-10-22-15-7-5-14(6-8-15)17-16(11-13(3)4)18(20)23-19(17)21/h5-9

is angiotensin receptor neprilysin inhibitor being studied for use in combination with valsartan for heart failure

R-GNE-140 - CAS# 2003234-63-5 size:2mg solid Kd= 650 nM)R GNE 140, CAS No. 2003234 63 5, a novel potent lactate dehydrogenase (LDHA) inhibitor with IC50 3nM for LDHA and 5 nM for LDHB. In MIA PaCa 2 human pancreatic cells, LDHA inhibition rapidly affected global metabolism, although cell death only occurred after 2 d of continuous LDHA inhibition. Pancreatic cell lines that utilize oxidative phosphorylation (OXPHOS) rather than glycolysis were inherently resistant to GNE 140, but could be resensitized to

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