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W-7 hydrochloride Catalog No.:M18510-C Structure-guided design and optimization of

SKU: 8254312861

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Description

Structure-guided design and optimization of small molecules targeting the protein-protein interaction between the von Hippel-Lindau (VHL) E3 ubiquitin ligase and the hypoxia inducible factor (HIF) alpha subunit with in vitro nanomolar affinities

InChi: InChI=1S/C41H72N2O6/c1-35(2

anntimigraine agent and antiserotonergic compound

27-nonaazahentriacontanamido)-17-(carboxymethyl)-8-(hydroxymethyl)-14-isopropyl-4

added 30 min prior to Carbachol treatment 48 h) fully abolishes carbachols timulated cell proliferation

W-7 hydrochloride Catalog No.:M18510-C Structure-guided design and optimization ofW 7 hydrochloride is a selective calmodulin antagonist. W 7 hydrochloride inhibits the Ca2+ calmodulin dependent phosphodiesterase and myosin light chain kinase with IC50 values of 28 M and 51 M, respectively. W 7 hydrochloride induces apoptosis and has antitumor activity. Product information CAS Number: 61714 27 0 Molecular Weight: 377. 33 Formula: C16H22Cl2N2O2S Chemical Name: N (6 aminohexyl) 5 chloronaphthalene 1 sulfonamide hydrochloride Smiles:

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