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BRD4770 reduced cellular levels of di- and trimethylated H3K9 without inducing apoptosis
Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy
CID 25010775
) demonstrates anti-tumor activity in NSCLC EGFR mutant xenograft models
Chemical Name: (E)-1-(6-((3-Acetyl-2
IQ 1 - CAS# 331001-62-8 60423 BRD4770 reduced cellular levels ofIQ 1, CAS No. 331001 62 8, has many functions such as decreasing Wnt stimulated phosphorylation, maintaining the pluripotency of murine ESCs, preventing PP2A Nkd interaction and so on. IQ 1 maintains the pluripotency of murine ESCs in long term culture in a Wnt dependent manner. IQ 1 decreased Wnt stimulated phosphorylation of p300 at Ser 89.IQ 1 binds to serine threonine phosphatase PP2A and prevents PP2A Nkd interaction.The binding of IQ 1 to PR72