PI-3065 Catalog No.:M8668-10 23 nM for NIK-catalyzed hydrolysis

23 nM for NIK-catalyzed hydrolysis of ATP to ADP

Formula: C16H19N3O4S

Smiles: CC(C)(C)NC(=O)NC1=NC2=NC(NCCCCN(CC)CC)=NC=C2C=C1C1C(Cl)=CC=CC=1Cl

Solubility: DMSO 100 mg/mL (180

a novel histamine H2-receptor antagonist

PI-3065 Catalog No.:M8668-10 23 nM for NIK-catalyzed hydrolysisPI3065 is a p110 isoform of phosphoinositide 3 OH kinase (PI(3)K) inhibitor. Inhibitors against the p110 isoform of phosphoinositide 3 OH kinase (PI(3)K) have shown remarkable therapeutic efficacy in some human leukaemias. As p110 is primarily expressed in leukocytes, drugs against p110 have not been considered for the treatment of solid tumours. p110 inactivation in regulatory T cells unleashes CD8(+) cytotoxic T cells and induces tumour regression.