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29)25(35)30-22(18-37-17-21-12-8-5-9-13-21)24(34)33-15-14-23-28(19-33
also known as Mardepodect
InChi: InChI=1S/C21H18Br2N2O/c22-14-6-8-20-18(10-14)19-11-15(23)7-9-21(19)25(20)13-17(26)12-24-16-4-2-1-3-5-16/h1-11
PubMed PMID: 25880547
(2011) Differentiation
SKP2-C25 - Skp2 Inhibitor. CAS# 222716-34-9 60149 29)25(35)30-22(18-37-17-21-12-8-5-9-13-21)24(34)33-15-14-23-28(19-33SKP2 C25, CAS No. 222716 34 9, is a potent, selective and cell permeable Skp2 inhibitor. It selectively inhibits Skp2 E3 ligase activity, but not activity of other SCF complexes. It also phenocopies the effects observed upon genetic Skp2 deficiency, such as suppressing survival and Akt mediated glycolysis and triggering p53 independent cellular senescence. SKP2 C25 exhibits potent antitumor activities in multiple animal models and cooperates with