Ku-55933 - CAS# 587871-26-9 0193 and serves as a basis

and serves as a basis for new selective inhibitors of other HDAC isoforms

and inhibits cell migration in NSCLC cells

orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer

Epub 2019 Jan 23

In the PC-3 model

Ku-55933 - CAS# 587871-26-9 0193 and serves as a basisKU 55933, CAS No. 587871 26 9, is an ATM inhibitor. KU 55933 blocks the phosphorylation of Akt induced by insulin and insulin like growth factor I in cancer cells that exhibit abnormal Akt activity. Moreover, KU 55933 inhibits cancer cell proliferation by inducing G(1) cell cycle arrest. It does so through the downregulation of the synthesis of cyclin D1, a protein known to be elevated in a variety of tumors. In addition, KU 55933 treatment during