PDE4B-IN-2 Size:Contact [email protected] for quotation Smiles: CCS(=O)(=O)NC1OC(C2C=CC(Cl)=CC=2)=C(O)C=1O

Smiles: CCS(=O)(=O)NC1OC(C2C=CC(Cl)=CC=2)=C(O)C=1O

InChi: InChI=1S/C30H36N4O2

Lurasidone dose-dependently inhibits TRY-induced forepaw clonic seizure and p-CAMP-induced hyperthermia in rats with ED50 of 5

crustaceans (Daphnia magna)

Currently a phase I study of MEK162 in patients with biliary tract cancer is undergoing

PDE4B-IN-2 Size:Contact [email protected] for quotation Smiles: CCS(=O)(=O)NC1OC(C2C=CC(Cl)=CC=2)=C(O)C=1OPDE4B IN 2 is an orally active and selective PDE4B inhibitor (IC50=15 nM) and exhibits >100 fold selectivity for PDE4B over 4D. PDE4B IN 2 regulates cAMP in inflammatory cells and inhibits LPS induced TNF production and neutrophil accumulation in mouse lungs. PDE4B IN 2 reduces microglial and neutrophil activation, and improves behavioral deficits in a traumatic brain injury model in vivo. PDE4B IN 2 also exhibits antidepressant like effects. Product