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Epub 2014 Jun 25
Trametinib specifically binds to and inhibits MEK 1 and 2
Chemical Name: 1-(4-((2-aminopyrimidin-4-yl)oxy)phenyl)-3-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)urea
leguminosarum lpxC is resistant to CHIR-090 up to 100 μg/mL
These findings suggest that LDN193189 might affect BMP-induced osteoblast differentiation
L-2-Hydroxyglutaric acid disodium 0302 Epub 2014 Jun 25L 2 Hydroxyglutaric acid disodium ((S) 2 Hydroxyglutaric acid disodium, L 2 Hydroxyglutarate disodium, LGA, L 2HG) is an epigenetic modifier and a putative oncometabolite in kidney cancer that inhibits histone demethylases and hence promotes histone methylation. L 2 Hydroxyglutaric acid disodium is also an inhibitor of mitochondrial creatine kinase (Mi CK) with Km and Ki of 2. 52 mM and 11. 13 mM, respectively. Product information CAS Number: 63512 50
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