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SMND-309 protects rat brains ischemia and reperfusion injury by targeting the JAK2/STAT3 pathway
the major human plasma metabolite of gefitinib
InChiKey: TYNLGDBUJLVSMA-UHFFFAOYSA-N
InChi: InChI=1S/C33H33N3O15/c1-3-43-29(38)17-4-6-18(7-5-17)34-31(39)49-26-25(14-37)48-30(42-2)28(51-33(41)36-20-9-11-22-24(13-20)47-16-45-22)27(26)50-32(40)35-19-8-10-21-23(12-19)46-15-44-21/h4-13
PubMed PMID: 22985969
(S, R, S)-AHPC-Me dihydrochloride 0275 SMND-309 protects rat brains ischemia(S,R,S) AHPC Me dihydrochloride (VHL ligand 2 dihydrochloride) is the (S,R,S) AHPC based VHL ligand used in the recruitment of the von Hippel Lindau (VHL) protein. (S,R,S) AHPC Me dihydrochloride can be used to synthesize ARV 771, a von Hippel Landau (VHL) E3 ligase based BET PROTAC degrader. ARV 771 potently degrades BET protein in castration resistant prostate cancer (CRPC) cells with a DC50 <1 nM. Product information Molecular Weight: 517. 51
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