AI-10-49 - CAS# 1256094-72-0 60268 tumor growth inhibition increases with

tumor growth inhibition increases with increased exposure of the compound and that tumor regressions could only be achieved when the compound exposure consistently exceeded 90% of c-MET inhibition

Remodelin was used at 1-10 µM in vitro and cellular assays

Therefore KDM5-C70 was developed as a pro-drug

particularly in the hippocampus

2017 Jan 1

AI-10-49 - CAS# 1256094-72-0 60268 tumor growth inhibition increases withAI 10 49, CAS No. 1256094 72 0, is an inhibitor that binds the transcription factor fusion CBF SMMHC. AI 10 49, that selectively binds to CBF SMMHC and disrupts its binding to RUNX1. AI 10 49 restores RUNX1 transcriptional activity, displays favorable pharmacokinetics, and delays leukemia progression in mice. Treatment of primary inv(16) AML patient blasts with AI 10 49 triggers selective cell death. These data suggest that direct inhibition of the