AK-7 - SIRT2 Inhibitor. CAS# 420831-40-9 size:2 mg solid InChi: InChI=1S/C14H14ClFN8/c1-7-3-11(24-23-7)21-13-10(15)6-19-14(22-13)20-8(2)12-17-4-9(16)5-18-12/h3-6

InChi: InChI=1S/C14H14ClFN8/c1-7-3-11(24-23-7)21-13-10(15)6-19-14(22-13)20-8(2)12-17-4-9(16)5-18-12/h3-6

685898-44-6

437(7057):436-9

selective and cell permeable Bromodomain Containing Protein 9 (BRD9) inhibitor with Kd ~1

Smiles: CN(C)CCCNC(=O)C1C=CC(=CC=1)C1=CC(O)=C2N=CC=CC2=C1

AK-7 - SIRT2 Inhibitor. CAS# 420831-40-9 size:2 mg solid InChi: InChI=1S/C14H14ClFN8/c1-7-3-11(24-23-7)21-13-10(15)6-19-14(22-13)20-8(2)12-17-4-9(16)5-18-12/h3-6AK 7, CAS No. 420831 40 9, is a cell and brain permeable, selective sirtuin SIRT2 inhibitor (IC50 ~15. 5 M). AK 7 displays no effect on SIRT1 or SIRT3. It diminishes neuronal cell death induced by mutant huntingtin fragment. It also down regulates cholesterol biosynthetic gene expression and reduces total cholesterol levels in neurons in vivo. In two genetic mouse models of Huntingtons disease, AK 7 treatment resulted in improved motor function,