Talsupram hydrochloride M 1000390 hydrochloride both Epothilone A and Taxol

both Epothilone A and Taxol don't share a common pharmacophore and exploits the tubulin-binding pocket uniquely and independently

Smiles: CC(=O)NC[C@H]1CN(C2C=CC(=C(F)C=2)N2CCOCC2)C(=O)O1

5 mg/kg causes a significant sensitization

a selective the cGMP-dependent protein kinase (PKG) inhibitor with an Ki value of 0

Immunoblotting time course demonstrates early repression of N-MYC expression within 2 h of treatment with ML327 (10 µM)

Talsupram hydrochloride M 1000390 hydrochloride both Epothilone A and TaxolProduct information CAS Number: 25487 28 9 Molecular Weight: 347. 95 Formula: C20H26ClNS Chemical Name: {3 [(1R) 3,3 dimethyl 1 phenyl 1,3 dihydro 2 benzothiophen 1 yl]propyl}(methyl)azanium chloride Smiles: [Cl ]. CC1(C)S[C@@](CCC[NH2+]C)(C2=CC=CC=C12)C1C=CC=CC=1 InChiKey: YMZCMCDSCRSIBS VEIFNGETSA N InChi: InChI=1S C20H25NS. ClH c1 19(2)17 12 7 8 13 18(17)20(22 19,14 9 15 21 3)16 10 5 4 6 11 16; h4 8,10 13,21H,9,14 15H2,1 3H3; 1H t20 ; m1. s1