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4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-6-(oxetan-3-ylamino)pyrimidine-4-carboxamide
with Kis of 8
InChiKey: ZCTCZKWJFTYNMZ-WKUCUCPSSA-J
25)/t12-/m0/s1
Totarol exhibited extremely weak inhibitory effects on HeLa cell proliferation
DLK-IN-1 Size:Contact [email protected] for quotation 4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-6-(oxetan-3-ylamino)pyrimidine-4-carboxamideDLK IN 1 is a selective, orally active inhibitor of dual leucine zipper kinase (DLK, MAP3K12), with a Ki of 3 nM. DLK IN 1 retains excellent CNS penetration and is well tolerated following multiple days of dosing at concentrations that exceed those required for DLK inhibition in the brain. DLK IN 1 has activity in a model of Alzheimers Disease. Product information CAS Number: 1620574 24 4 Molecular Weight: 423. 43 Formula: C20H24F3N5O2 Chemical Name:
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