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Activation of the PI3K signaling pathway is frequently associated with tumorigenesis
axonal loss and APP positivein spinal cord of Fasudil-treated mice via p
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54(8):2592-601
InChi: InChI=1S/C28H30Cl3N7O5S/c1-37(2)10-4-7-24(39)33-19-5-3-6-20(15-19)44(42
IWP-O1 - CAS# 2074607-48-8 size:10mg solid Activation of the PI3K signalingIWP O1, CAS No. 2074607 48 8, is highly potent Porcn inhibitor, The acyltransferase Porcupine (Porcn) is essential for the secretion of Wnt proteins which contribute to embryonic development, tissue regeneration, and tumorigenesis. IWP O1 has an EC50 value of 80pM in a cultured cell reporter assay of Wnt signaling. Additionally, IWP O1 has significantly improved metabolic stability over our previously reported Porcn inhibitors. Product information CAS