Dasatinib Size:Solid 10 mg 3 Å resolution co-complex structure

3 Å resolution co-complex structure of hGPR40-TAK-875 reveals a unique binding mode of TAK-875 and suggests that entry to the non-canonical binding pocket most probably occurs via the lipid bilayer

Smiles: CN1NC(=O)C(=O)N=C1SCC1CS[C@@H]2[C@H](NC(=O)/C(=N\OC)/C3=CSC(N)=N3)C(=O)N2C=1C(O)=O

Bayoumi AH

1093/bioinformatics/bts702

Kitamura H

Dasatinib Size:Solid 10 mg 3 Å resolution co-complex structureDasatinib is a potent inhibitor of the non receptor tyrosine kinases Abl and Src as well as other members of the Src family. Dasatinib may have therapeutic value in fibrotic diseases characterized by elevated levels of Abl and Src kinases. Product information CAS Number: 302962 49 8 Molecular Weight: 488. 01 Formula: C22H26ClN7O2S Chemical Name: N (2 chloro 6 methylphenyl) 2 ({6 [4 (2 hydroxyethyl)piperazin 1 yl] 2 methylpyrimidin 4 yl}amino) 1,3