FPS-ZM1 - CAS# 945714-67-0 0078 inducing epigenetic changes in leukemia

inducing epigenetic changes in leukemia cells and the expression of promoter methylated genes

InChiKey: TXJZRSRTYPUYRW-NQIIRXRSSA-N

Chemical Name: (S)-(4-fluorophenyl)(3-(3-(4-fluorophenyl)-1

and 2a (JFH-1)-derived replicons and GT 1b chimeric replicons containing the NS5B region from the J6 GT 2a isolate and from GT 2b and GT 3a patient isolates is evaluated

SK-MEL-28 and A375 (IC50 from 30-250 nM)

FPS-ZM1 - CAS# 945714-67-0 0078 inducing epigenetic changes in leukemiaFPS ZM1, CAS No. 945714 67 0, is a high affinity RAGE specific blocker that inhibits amyloid binding to RAGE, neurological damage and inflammation in the APP(sw 0) transgenic mouse model of AD. FPS ZM1 is not toxic to mice and can easily cross the blood brain barrier. AGEs administration induced an regulation of Abeta production, inflammation, and oxidative stress, and an increased escape latency of rats in the Morris water maze test, all of these are