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and reactivation from latency
Oksenberg D
PubMed PMID: 26259519
75(6):1588-1590
acting as an androgen receptor degrader
Ispinesib (SB-715992) st N-oxide and reactivation from latencyIspinesib is a synthetic small molecule, derived from quinazolinone, with antineoplastic properties. Ispinesib selectively inhibits the mitotic motor protein, kinesin spindle protein (KSP), resulting in inhibition of mitotic spindle assembly, induction of cell cycle arrest during the mitotic phase, and cell death in tumor cells that are actively dividing. Because KSP is not involved in nonmitotic processes, such as neuronal transport, ispinesib may be
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