![CX-5461 - RNA Polymerase I inhibitor. CAS# 1138549-36-6 0179 4]triazolo[1](https://cdn.shopify.com/s/files/1/0389/1897/9723/products/xcessbio1409726562.1472558.png?v=1742658123)
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4]triazolo[1
56(19):7498-500
InChiKey: PNYRDVBFYVDJJI-UHFFFAOYSA-N
CAS Number: 1448347-49-6
It does not interact with the bromodomains of BRD4(BD1)
CX-5461 - RNA Polymerase I inhibitor. CAS# 1138549-36-6 0179 4]triazolo[1CX 5461, CAS No. 1138549 36 6, is a first in class non genotoxic small molecule targeted inhibitor of RNA polymerase I (Pol I) that activates the p53 pathway without causing DNA damage. CX 5461 selectively inhibits rRNA synthesis by Pol I in the nucleolus, but does not inhibit mRNA synthesis by RNA Polymerase II (Pol II) and does not inhibit DNA replication or protein synthesis. Inhibition of Pol I results in nucleolar stress and release of ribosomal