AST 487 - CAS# 630124-46-8 Size:Solid 2 mg PND-1186 treatment caused downregulation of

PND-1186 treatment caused downregulation of FAK Tyr-397 phosphorylation and cyclin D1 amount (Supplementary Figures S8c and d) and increased the expression of both p21 and cleaved caspase-3 at 48 h (Figure 8b)

InChiKey: PJDFLNIOAUIZSL-UHFFFAOYSA-N

4-dimethoxypyridin-2-yl)methanesulfinyl]-1H-1

HG-9-91-01 is a potent and highly selective salt-inducible kinase (SIKs) inhibitor for SIK1

3-1(4)2(5)6/h2*2

AST 487 - CAS# 630124-46-8 Size:Solid 2 mg PND-1186 treatment caused downregulation ofAST487, also known as NVP AST487, is a RET kinase inhibitor FLT3 inhibitor. The RET kinase has emerged as a promising target for the therapy of medullary thyroid cancers (MTC) and of a subset of papillary thyroid cancers. NVP AST487 has an IC(50) of 0. 88 mumol L on RET kinase, inhibits RET autophosphorylation and activation of downstream effectors, and potently inhibited the growth of human thyroid cancer cell lines with activating mutations of RET