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Smiles: CCCC1=CC2=C(N=CN=C2S1)N1CCN(CC1)C1=NCC(C)(C)S1
Ayrapetov MK
It has been shown to promote goblet cell differentiation in mouse intestine
Chemical Name: 5-chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidine-2
Formula: C24H23N5O2
PBIT - JARID1 Histone Demethylases Inhibitor. CAS# 2514-30-9 Catalog No.:M60170-10S Smiles: CCCC1=CC2=C(N=CN=C2S1)N1CCN(CC1)C1=NCC(C)(C)S1PBIT, CAS No. 2514 30 9, is a potent, specific, reversible and cell permeable inhibitor of Jumonji AT Rich Interactive Domain 1 (JARID1) histone demethylases. It inhibits JARID1B (also known as KDM5B or PLU1) with an IC of ~3 M in vitro. It also inhibits the activity of other related histone demethylases JARID1A, JARID1C, and JMJD2E with IC50 ~6, 4. 9, and 28 M respectively. PBIT does not affect the activity of unrelated UTX and JMJD3 H3K27me3
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