NC1=NC=CC2C=CN=CC=21)NC1=C(Br)C(=O)C21CCCCC2](https://cdn.shopify.com/s/files/1/0389/1897/9723/products/M26259_1635975437.gif?v=1635975439)
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Smiles: CCOC(=O)[C@H](CC1C=CC(=CC=1)NC1=NC=CC2C=CN=CC=21)NC1=C(Br)C(=O)C21CCCCC2
most importantly
6R)-6-methoxycyclohexane-1
Crenolanib (1 nM-10 μM) stimulates ABCB1 ATPase activity in a concentration-dependent manner
natriuretic and K+ and Cl- sparing effect of Fr•EtOAc in rats
SAR-020106 22279 Smiles: CCOC(=O)[C@H](CC1C=CC(=CC=1)NC1=NC=CC2C=CN=CC=21)NC1=C(Br)C(=O)C21CCCCC2SAR 020106 is an ATP competitive, potent, and selective CHK1 inhibitor with an IC50 of 13. 3 nM for human CHK1. SAR 020106 shows excellent selectivity over CHK2. SAR 020106 significantly enhances the cell killing of Gemcitabine and SN38 by 3 to 29 fold in several colon tumor lines and in a p53 dependent fashion. SAR 020106 can enhance antitumor activity with selected anticancer drugs. Product information CAS Number: 1184843 57 9 Molecular Weight: 382.
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