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Epub 2014 Jun 21
is an active constituent of Wikstroemia indica C
Formula: C28H41N7O3
and Aurora kinase
DeBerardinis RJ
Palomid 529 (P529) spladib) Epub 2014 Jun 21Palomid 529, also known as P529, is a novel PI3K Akt mTOR inhibitor. Palomid 529 (P529) inhibits the TORC1 and TORC2 complexes and shows both inhibition of Akt signaling and mTOR signaling similarly in tumor and vasculature. It was demonstrated that P529 inhibited tumor growth, angiogenesis, and vascular permeability. It retained the beneficial aspects of tumor vascular normalization that rapamycin boasts. However, P529 showed the additional benefit
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