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CO-1686 (50 mg/kg bid
PubMed Central PMCID: PMC4309183
Resmetirom
1021/jm4019299
9 mg/kg per day for 14 days
ABT-888 dihydrochloride - CAS# 912445-05-7 0109 CO-1686 (50 mg/kg bidABT 888 dihydrochloride, also known asVeliparib, CAS No. 912445 05 7, is a potent and selective Poly (ADP Ribose) Polymerase (PARP) Inhibitor. ABT 888 dihydrochloride enhances apoptosis and autophagy in response to treatments that cause DNA breaks, including radiation and DNA alkylation. ABT 888 dihydrochloride is an orally bioavailable inhibitor of PARP1 and PARP2 (Kis = 5. 2 and 2. 9 nM, respectively). Product information CAS Number: 912445 05 7