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PubMed PMID: 31432436
Chemical Name: (13R
DDO-5936 shows limited oral efficiency
9'-xanthen]-5-yl}carbamothioyl)amino]ethoxy}ethoxy)ethoxy]ethyl}carbamate
with antimitotic
F-1 Catalog No.:M26247-C PubMed PMID: 31432436F 1 is a potent ALK and ROS1 dual inhibitor, suppresses phospho ALK and its relative downstream signaling pathways, with IC50s of 2. 1 nM, 2. 3 nM, 1. 3 nM and 3. 9 nM for ALKWT, ROS1WT, ALKL1196M and ALKG1202R, respectively. Product information CAS Number: 2244775 31 1 Molecular Weight: 519. 02 Formula: C22H27ClN8O3S Chemical Name: N {2 [(5 chloro 2 {[2 methoxy 6 (4 methylpiperazin 1 yl)pyridin 3 yl]amino}pyrimidin 4
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