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a significant and rapid reduction in leukemia burden was observed
InChiKey: GFARQYQBWJLZMW-JYFOCSDGSA-N
Atglistatin hydrochloride was generated by the addition of 25% HCl
and JMJD2E with IC50 ~6
It competes with acetyl-CoA for the p300 Lys-CoA binding pocket selectively
MALT1-MI-2 (MI-2) - MALT1 inhibitor. CAS# 1047953-91-2 429 a significant and rapid reductionMALT1 MI 2 (MI 2), CAS No. 1047953 91 2, is a highly potent and selective small molecule directly binding to MALT1 and irreversibly suppressing its protease function. MI 2 concentrated within human ABC DLBCL cells and irreversibly inhibited cleavage of MALT1 substrates with EC50 < 1 M (HBL 1 ~200 nM; TMD8 ~500 nM). This was accompanied by NF B pathway suppression, c REL nuclear localization inhibition, and NF B target gene downregulation. MI 2 was