BMS-265246 175 Halofuginone competitively inhibits prolyl-tRNA synthetase

Halofuginone competitively inhibits prolyl-tRNA synthetase by occupying both the prolineand tRNA-binding pockets of prolyl-tRNA synthetase

YM-201636 at 160 nM inhibits PtdIns5P synthesis twice more effectively compared with PtdIns(3

Solubility: DMSO: 50

2015 Nov 5

InChi: InChI=1S/C20H22O6/c1-8(2)18-13(25-18)14-20(26-14)17(3)5-4-9-10(7-23-15(9)21)11(17)6-12-19(20

BMS-265246 175 Halofuginone competitively inhibits prolyl-tRNA synthetaseBMS 265246 is a potent CDK1 CDK2 selective inhibitor [(CDK1 cycB IC(50)=6 nM, CDK2 cycE IC(50)=9 nM)]. Product information CAS Number: 582315 72 8 Molecular Weight: 345. 34 Formula: C18H17F2N3O2 Chemical Name: 4 butoxy 5 (2,6 difluoro 4 methylbenzoyl) 2H pyrazolo[3,4 b]pyridine Smiles: CC1C=C(F)C(=C(F)C=1)C(=O)C1C=NC2=NNC=C2C=1OCCCC InChiKey: SCFMWQIQBVZOQR UHFFFAOYSA N InChi: InChI=1S C18H17F2N3O2 c1 3 4 5 25 17 11(8 21 18 12(17)9 22 23 18)16(24)15