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CAS Number: 865231-46-5
Nutlin-3a suppresses xenograft growth in a dose-dependent fashion with the highest dose (200 mg/kg) showing a substantial tumor shrinkage
PubMed Central PMCID: PMC3500996
CAS Number: 26807-65-8
AZD1208 - CAS# 1204144-28-4 Size:Solid 2 mg the United States (UAZD1208 is orally available, small molecule inhibitor of PIM kinases with potential antineoplastic activity. Pan PIM kinase inhibitor AZD1208 inhibits the activities of PIM1, PIM2 and PIM3 serine threonine kinases, which may result in the interruption of the G1 S phase cell cycle transition, thereby causing cell cycle arrest and inducing apoptosis in cells that overexpress PIMs. The growth inhibition of several leukemia cell lines by this agent is
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