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Smiles: CCC(=O)NCC[C@@H]1CCC2=CC=C3OCCC3=C21
All other kinases tested have IC50 values 50-fold greater than that for CK2
Formula: C10H9NO2
Gemcitabine is an analogue of the antimetabolite nucleoside deoxycytidine with antineoplastic activity
The chemical is currently used by researchers interested in studying neuronal transmission with a high-affinity
Valproic acid - CAS# 99-66-1 Size:Solid 2 mg Smiles: CCC(=O)NCC[C@@H]1CCC2=CC=C3OCCC3=C21AI 10 49 is an inhibitor that binds the transcription factor fusion CBF SMMHC. AI 10 49, that selectively binds to CBF SMMHC and disrupts its binding to RUNX1. AI 10 49 restores RUNX1 transcriptional activity, displays favorable pharmacokinetics, and delays leukemia progression in mice. Treatment of primary inv(16) AML patient blasts with AI 10 49 triggers selective cell death. These data suggest that direct inhibition of the oncogenic CBF SMMHC
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