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4 mg/mL (6
Inhibitory effect on mitosis
DNA and protein analysis in Ionomycin-treated cultures revealed DNA fragmentation and PARP cleavage to an 85-kDa fragment typical of caspase-mediated apoptosis
resulting in decreased expression of mRNAs necessary for cell cycle progression and arresting cells in the G1 phase of the cell cycle
140(10):632-639
GSK-J4 hydrochloride Catalog No.:M15021-2 4 mg/mL (6GSK J4 hydrochloride is a potent dual inhibitor of H3K27me3 me2 demethylases JMJD3 KDM6B and UTX KDM6A with IC50s of 8. 6 and 6. 6 M, respectively. GSK J4 hydrochloride inhibits LPS induced TNF production in human primary macrophages with an IC50 of 9 M. GSK J4 hydrochloride is a cell permeable prodrug of GSK J1. Product information CAS Number: 1797983 09 5 Molecular Weight: 453. 96 Formula: C24H28ClN5O2 Chemical Name: ethyl 3 {[2 (pyridin 2 yl) 6
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