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CFI-402257 exerts potent growth inhibitory activity across the vast majority of cell lines with a median IC50 value of 15 nM
Doherty AM
It also inhibits other TAIRE kinase family members
Chemical Name: 5-(4-Chloro-phenyl)-3-phenyl-pent-2-enoic acid
Chemical Name: Benzamide
BAY-1251152 racemate - CAS# 1610358-53-6 0158 CFI-402257 exerts potent growth inhibitoryBAY 1251152 racemate, CAS No. 1610358 53 6, also known as () BAY 1251152, is a racemic mixture of BAY 1251152. BAY 1251152 is a potent and highly selective PTEF CDK9 inhibitor. BAY 1251152 racemate, CAS No. 1610358 53 6, binds to and blocks the phosphorylation and kinase activity of CDK9, thereby preventing PTEFb mediated activation of RNA Pol II and leading to the inhibition of gene transcription of various anti apoptotic proteins. This may cause
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