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InChi: InChI=1S/C20H17NO5/c1-3-12-26-17-10-8-14(13-18(17)25-2)9-11-19(22)21-16-7-5-4-6-15(16)20(23)24/h1
Epub 2019 Jul 2
MD-224 (30 nM
(R)-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible
1993 Sep 1
PD173955 - CAS# 260415-63-2 Catalog No.:M11371-2 InChi: InChI=1S/C20H17NO5/c1-3-12-26-17-10-8-14(13-18(17)25-2)9-11-19(22)21-16-7-5-4-6-15(16)20(23)24/h1PD 173955 is a src tyrosine kinase inhibitor. PD173955 inhibited Bcr Abl dependent cell growth. PD173955 showed cell cycle arrest in G(1). PD173955 has an IC(50) of 1 2 nM in kinase inhibition assays of Bcr Abl, and in cellular growth assays it inhibits Bcr Abl dependent substrate tyrosine phosphorylation. PD173955 inhibited kit ligand dependent c kit autophosphorylation (IC(50) = approximately 25 nM) and kit ligand dependent proliferation of M07e