Nabumetone Catalog No.:M8907-2 21-dodecaen-9-yl]propanoic acid

21-dodecaen-9-yl]propanoic acid

InChi: InChI=1S/C22H25N3O3/c26-14-13-25(12-11-19-15-23-21-4-2-1-3-20(19)21)16-18-7-5-17(6-8-18)9-10-22(27)24-28/h1-10

PubMed PMID: 26032411

InChiKey: ZSTLCHCDLIUXJE-GMLJRNIPSA-N

and the cytotoxicity by SKI-II was almost reversed by the general caspase inhibitor z-VAD-fmk

Nabumetone Catalog No.:M8907-2 21-dodecaen-9-yl]propanoic acidNabumetone is a non steroidal anti inflammatory drug (NSAID), the only 1 naphthaleneacetic acid derivative. It is a nonacidic NSAID that is rapidly metabolized in the liver to a major active metabolite, 6 methoxy 2 naphthyl acetic acid. As found with previous NSAIDs, nabumetone's active metabolite inhibits the cyclooxygenase enzyme and preferentially blocks COX 2 activity (which is indirectly responsible for the production of inflammation and pain