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is a synthetic quinolone derivative and dual kinase inhibitor that targets both Abl and Src kinases with potential antineoplastic activity
induces apoptosis and pro-death autophagy in A549 lung cancer cells
InChi: InChI=1S/C36H52O11/c1-6-7-19-35(47-34(44)17-16-32(40)41)21-22-36(46-30(35)14-10-25(3)23-33(42)43)20-18-27(5)29(45-36)13-9-24(2)8-12-28(37)26(4)11-15-31(38)39/h8-12
InChiKey: HMTFXPJOBPIOIN-DKBYMCRTSA-N
InChi: InChI=1S/C17H13N5O2/c1-10-20-12-5-4-11(9-15(12)24-10)21-17(23)22-14-6-8-18-13-3-2-7-19-16(13)14/h2-9H
ANI-7 EG1-COOH is a synthetic quinolone derivativeANI 7 is an activator of aryl hydrocarbon receptor (AhR) pathway. ANI 7 inhibits the growth of multiple cancer cells, and potently and selectively inhibits the growth of MCF 7 breast cancer cells with a GI50 of 0. 56 M. ANI 7 induces CYP1 metabolizing mono oxygenases by activating AhR pathway, and also induces DNA damage, checkpoint Kinase 2 (Chk2) activation, S phase cell cycle arrest, and cell death in sensitive breast cancer cell lines. Product
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