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ITF2357 reduces cytokines and protects islet β cells in vivo and in vitro
InChiKey: NDVQUNZCNAMROD-RZUBCFFCSA-N
Epub 2019 Mar 31
InChi: InChI=1S/C13H27BN2O4/c15-13(12(17)18
18(6):1965-1971
Elacridar Hydrochloride ron ITF2357 reduces cytokines and protectsElacridar, also known as GF120918A, is a P glycoprotein (P gp) inhibitor, and has been used both in vitro and in vivo as a tool inhibitor of P glycoprotein (Pgp) to investigate the role of transporters in the disposition of various test molecules. In vitro, GF120918A demonstrated high plasma protein binding across species, although a definitive protein binding evaluation was precluded by poor recovery, particularly in buffer and in mouse, rat, and dog
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