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At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature protease
The latter domain is composed of alternating hydrophobic and hydrophilic segments
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run a sample suitability (matrix interference) test and use spiked recovery to validate the assay
Jul 2008] Swissprot No P26038 Gene Accession 4478 WB Predicted band size 68 kDa WB Positive control WB Recommended dilution 500-2000 IHC predicted cell location Predicted cell location: Cytoplasm IHC positive control Positive control: Human lung cancer IHC Recommed dilution Recommended dilution: 50-100 Storage
Human GPC3 Package Size:10ug At least one of theseGPC (glypicans) are a family of heparan sulfate proteoglycans that are attached to the cell surface by a glycosylphosphatidylinositol anchor. Mutations in GPC3 cause a rare disorder in humans, Simpson Golabi Behmel Syndrome. Glypican 3 has been implicated in regulating many different signaling pathways including: IGF, FGF, BMP and Wnt, but it is required for an endoproteolytic processing of GPC3 for the modulation of Wnt signaling (1 5).